The Effect of SP/NK1R on the Expression and Activity of Catalase and Superoxide Dismutase in Glioblastoma Cancer Cells

Figure 7

Schematic representation proposed for the plausible mechanisms through which aprepitant could prevent the effects of SP/NK1R on the antioxidant balance in glioblastoma-derived U87 cells. While the interaction between SP and NK1R in U87 cells increased the intracellular level of ROS via suppressing the enzymatic activity of catalase and SOD, blockage of NK1R using aprepitant altered the oxidative balance of the cells. As presented, aprepitant increased both the expression and the enzymatic activity of catalase and SOD, which in turn abolish the production of ROS from the mitochondria, an event that leads to the reduction in the survival and the proliferative capacity of the cells.

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