Synthesis, DFT Analysis, and Evaluation of Antibacterial and Antioxidant Activities of Sulfathiazole Derivatives Combined with In Silico Molecular Docking and ADMET Predictions

Table 1

Zone of bacterial growth inhibition diameter (mm).

Compounds	Conc.	Inhibition diameter (mm)±SD
		E. coli	P. aeruginosa	S. pyogenes	S. aureus
7	50 mg/mL	6.95 ± 0.777	7.20 ± 1.555	7.35 ± 0.636	6.70 ± 0.013
	25 mg/mL	8.10 ± 0.848	6.75 ± 1.060	6.60 ± 0.424	6.20 ± 0.282
	12.5 mg/mL	6.35 ± 0.495	6.20 ± 0.282	6.00 ± 0.011	6.00 ± 0.031
11a	50 mg/mL	11.6 ± 0.283	7.75 ± 0.353	7.25 ± 0.353	7.30 ± 0.283
	25 mg/mL	11.1 ± 0.141	8.15 ± 0.495	10.95 ± 0.07	9.15 ± 0.495
	12.5 mg/mL	8.35 ± 0.212	7.35 ± 1.202	6.35 ± 0.212	6.65 ± 0.071
11b	50 mg/mL	7.10 ± 0.141	7.80 ± 0.015	6.15 ± 0.070	6.45 ± 0.495
	25 mg/mL	7.00 ± 0.707	7.35 ± 0.777	6.05 ± 0.070	6.15 ± 0.212
	12.5 mg/mL	7.65 ± 0.212	7.50 ± 0.141	6.20 ± 0.013	6.65 ± 0.212
Sulfamethoxazole	23.75 μg/mL	15.7 ± 0.707	16.7 ± 0.636	15.3 ± 2.687	12.8 ± 3.252