Structural Predictive Model of Presenilin-2 Protein and Analysis of Structural Effects of Familial Alzheimer’s Disease Mutations

Figure 7

Structural and electronic changes of mutation Thr122Arg. (a) Potential-potential surfaces of wild type (left) and mutation Thr122Arg (right). (b) Electrostatic potential map for the vicinity of the position 122–126 in the guanidine-PS2 protein, wild-type protein (Left) and mutation Thr122Arg (Right).

(a)

(b)