Hypoxia-Induced miR-210 Promotes Endothelial Cell Permeability and Angiogenesis via Exosomes in Pancreatic Ductal Adenocarcinoma

Figure 7

Exosomal miR-210 promotes tumor progression via EFNA3 PI3K/AKT/VEGFA or EFNA3/Wnt/Β-catenin/RHOA (a) The in vitro angiogenesis abilities of the indicated treated HUVECs were measured by tube formation assays. Magnification, ×200. (b) Relative expression of the indicated proteins in the indicated HUVECs was measured by WB analysis. (c) In the transwell assay, the tumor cells that passed through the endothelial monolayer were imaged by fluorescence microscopy. Magnification, ×100.

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