miR-21 Regulates Immune Balance Mediated by Th17/Treg in Peripheral Blood of Septic Rats during the Early Phase through Apoptosis Pathway

Figure 1

The proportions of lymphocytes and inflammatory factors were changed in peripheral blood of septic rats. (a) The ratios of CD4+ T cells in peripheral blood in eight-paired NC rat group and SP rat group were determined by flow cytometry [t value = 14.213,  < 0.01]. ((b) and (c)) The levels of IL-17 and IL-10 in peripheral blood in eight-paired NC rat group and SP rat group were determined by ELISA [t value (IL-17) = 16.892,  < 0.01; t value (IL-10) = 16.312,  < 0.01]. (d) The ratio of Th17 cells in peripheral blood in eight-paired NC rat group and SP rat group were determined by flow cytometry [t value = 5.687,  < 0.01]. (e) The ratios of Treg cells in peripheral blood in eight-paired NC rat group and SP rat group were determined by flow cytometry [t value = 5.482,  < 0.01]. NC group: normal control group; SP group: sepsis group.  < 0.01.

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