Research Article
MicroRNA-Based Markers of Oral Tongue Squamous Cell Carcinoma and Buccal Squamous Cell Carcinoma: A Systems Biology Approach
Table 2
A total of 96 nodes demonstrated high centrality values in the PPI network associated with OTSCC and BSCC and considered hub genes.
| Gene symbols | Degrees | Betweenness | Closeness |
| MYC | 149 | 0.076 | 0.483 | HSP90AA1 | 130 | 0.060 | 0.472 | HSPA5 | 78 | 0.033 | 0.435 | PTEN | 106 | 0.032 | 0.449 | FN1 | 88 | 0.026 | 0.425 | MDM2 | 76 | 0.026 | 0.432 | MAPT | 65 | 0.025 | 0.427 | MAPK1 | 76 | 0.023 | 0.431 | SMAD4 | 73 | 0.018 | 0.418 | RAC1 | 62 | 0.018 | 0.410 | GSK3B | 72 | 0.017 | 0.427 | CCNB1 | 59 | 0.017 | 0.416 | CUL1 | 48 | 0.017 | 0.398 | CCND1 | 84 | 0.016 | 0.428 | ARF1 | 37 | 0.016 | 0.382 | FOS | 62 | 0.016 | 0.416 | HIF1A | 75 | 0.016 | 0.428 | HIST2H2BE | 67 | 0.016 | 0.414 | HNRNPC | 75 | 0.015 | 0.417 | CANX | 44 | 0.015 | 0.396 | NCL | 62 | 0.014 | 0.414 | CAV1 | 57 | 0.014 | 0.414 | PPP1CB | 49 | 0.014 | 0.407 | G3BP1 | 55 | 0.014 | 0.409 | GRIA2 | 43 | 0.013 | 0.390 | HUWE1 | 46 | 0.013 | 0.401 | FMR1 | 49 | 0.013 | 0.409 | DICER1 | 51 | 0.012 | 0.402 | PUM2 | 41 | 0.012 | 0.385 | STAT1 | 51 | 0.012 | 0.406 | IGF1R | 54 | 0.012 | 0.419 | NRXN1 | 39 | 0.011 | 0.379 | NTRK2 | 38 | 0.011 | 0.389 | SRSF1 | 68 | 0.011 | 0.407 | RANBP2 | 43 | 0.011 | 0.395 | UBE3A | 41 | 0.011 | 0.403 | DDX5 | 52 | 0.011 | 0.400 | SEC13 | 41 | 0.011 | 0.384 | UBE4B | 30 | 0.011 | 0.375 | PTPN11 | 46 | 0.010 | 0.399 | P4HB | 41 | 0.010 | 0.389 | IQGAP1 | 48 | 0.010 | 0.406 | TRIP12 | 36 | 0.010 | 0.384 | HNRNPH1 | 56 | 0.010 | 0.393 | YWHAG | 34 | 0.010 | 0.393 | CYCS | 49 | 0.009 | 0.411 | HNRNPD | 51 | 0.009 | 0.398 | YAP1 | 44 | 0.009 | 0.395 | DHX15 | 56 | 0.009 | 0.387 | VCL | 41 | 0.009 | 0.384 | QKI | 33 | 0.009 | 0.387 | DDB1 | 40 | 0.009 | 0.392 | CRK | 35 | 0.009 | 0.386 | RAN | 43 | 0.009 | 0.387 | XRCC5 | 44 | 0.008 | 0.396 | SNRPF | 45 | 0.008 | 0.371 | EIF2S1 | 43 | 0.008 | 0.400 | CD44 | 57 | 0.008 | 0.402 | TLR4 | 48 | 0.008 | 0.397 | CHD4 | 56 | 0.008 | 0.391 | CFL1 | 39 | 0.008 | 0.392 | KDM6A | 42 | 0.008 | 0.391 | H2AFV | 42 | 0.008 | 0.379 | CALR | 40 | 0.008 | 0.399 | PPP2R1A | 35 | 0.008 | 0.397 | USP9X | 36 | 0.007 | 0.390 | XIAP | 42 | 0.007 | 0.404 | DDX17 | 45 | 0.007 | 0.394 | MATR3 | 46 | 0.007 | 0.393 | SP1 | 36 | 0.007 | 0.391 | SOD1 | 36 | 0.007 | 0.399 | HNRNPDL | 48 | 0.007 | 0.392 | PTGES3 | 37 | 0.007 | 0.390 | PRPF8 | 46 | 0.007 | 0.380 | SKIV2L2 | 43 | 0.007 | 0.364 | PUM1 | 35 | 0.007 | 0.370 | TRRAP | 36 | 0.007 | 0.383 | EWSR1 | 43 | 0.007 | 0.398 | NEDD4 | 30 | 0.006 | 0.384 | FLNA | 44 | 0.006 | 0.390 | UBQLN2 | 38 | 0.006 | 0.394 | PKM | 35 | 0.006 | 0.396 | WDR82 | 35 | 0.006 | 0.374 | RBFOX1 | 29 | 0.006 | 0.364 | MYH9 | 31 | 0.006 | 0.379 | KPNA2 | 35 | 0.005 | 0.391 | AKT3 | 29 | 0.005 | 0.383 | ATRX | 41 | 0.005 | 0.384 | TGFBR2 | 38 | 0.005 | 0.387 | MMP2 | 47 | 0.005 | 0.385 | MBNL1 | 30 | 0.005 | 0.368 | TCP1 | 33 | 0.005 | 0.381 | EIF3A | 31 | 0.005 | 0.364 | ANXA5 | 50 | 0.005 | 0.412 | MMP9 | 52 | 0.005 | 0.400 | SMARCB1 | 41 | 0.005 | 0.389 |
|
|
PPI, protein-protein interaction; OTSCC, oral tongue squamous cell carcinoma; BSCC, buccal squamous cell carcinoma.
|