Selective Decontamination of the Digestive Tract Reduces Pneumonia and Mortality

Table 2

Incidence and relative risks of pneumonia and mortality in trials of SDD in mixed medical-surgical ICUs.

Publication	Year	𝑁	Incidence of pneumonia (%)	ICU Mortality (%)
			SDD versus control (RR [95% confidence interval])
Ledingham [20]	1988	324	3 versus 9%, 𝑃=.006	24 versus 24%, ns
Ulrich [4]	1989	100	6 versus 44%, 𝑃<.00001	31 versus 54%, 𝑃<.02
			(0.28 [0.13–0.59])	(0.69 [0.47–1.02])
Godard [21]	1990	181	2 versus 15%, 𝑃<.05	12 versus 18%, ns
McClelland [22]	1990	27	7 versus 50%, 𝑃<.05	60 versus 58%, ns
Aerdts [23]	1991	56	6 versus 62%, 𝑃=.0001	12 versus 10%, ns
			(0.09 [0.01–0.60])	(0,71 [0.25–2.02])
Blair [24]	1991	256	48 versus 82%, 𝑃=.002	15 versus 19%, ns
			(0.33 [0.18–0.62])	(0.17 [0.49 – 1.28])
Finch [25]	1991	49	0.69 [0.23–2.01], ns	1.56 [0.88–2.77], ns
Gaussorgues [26]	1991	118	N.A.	1.00 [0.69–1.44], ns
Cockerill [27]	1992	150	5 versus 16%, 𝑃=.03	11 versus 19%, ns
			0.33 [0.11–0.99]	0.69 [0.34–1.38]
Hammond [28]	1992	239	26 versus 34%, 𝑃=.22	12 versus 12%, ns
			0.82 [0.51–1.34]	1.08 [0.70–1.67]
Jacobs [29]	1992	91	0 versus 9%, ns	39 versus 53%, ns
			0.13 [0.02–0.95]	0.62 [0.37–1.05]
Rocha [5]	1992	101	15 versus 46%, 𝑃<.001	21 versus 44%, 𝑃<.05
			0.32 [0.15–0.68]	0.70 [0.49–1.02]
Winter [30]	1992	183	3 versus 18%, 𝑃<.05	36 versus 43%, ns
			0.18 [0.05–0.59]	0.83 [0.58–1.19]
Ferrer [31]	1994	80	18 versus 24%, ns	31 versus 27%, ns
			0.70 [0.33–1.46]	1.21 [0.63–2.34]
Palomar [32]	1997	129	17 versus 50%, 𝑃=.005	24 versus 31%, ns
			0,39 [0,21–0,73]	0,98 [0,52–1,84]
Verwaest [33]	1997	440	9 versus 18%, 𝑃=.026	18 versus 17%, ns
			0.53 [0.34–0.89]	1,17 [0.81–1.71]
Sánchez-García [34]	1998	271	11 versus 29%, 𝑃<.001	39 versus 47%, ns
			0.57 [0.40–0.81]	0.84 [0.63–1.11]
Parra Moreno [35]	2002	306	5 versus 20%, 𝑃<,0001	N.A.
			0.30 [0.16–0.53]
De Jonge [36]	2003	934	N.A.	15 versus 23%, 𝑃=.002
				0.65 [0.49–0.85]
De Smet [37]	2009	4035	N.A.	3.5% points absolute reduction, 𝑃=.02
				0.81 [0.69–0.94]

𝑁: number of patients; ns: not significant; N.A.: not available.