Use of Physiologic Reasoning to Diagnose and Manage Shock States
Table 2
Disruptions in the normal economy of oxygen supply and demand can have profound impacts on solid organ function and long-term outcomes. Typically, changes in metabolic mode from aerobic to anaerobic as evidenced by high lactate or decreased central oxyhemoglobin saturation (sCVO2) can be explained by changes in either supply, demand, or both. Except in rare instances of hypermetabolism, most pathology in oxygen supply/demand can be traced to problems with delivery (DO2).