Positive Fluid Balance Is Associated with Higher Mortality and Prolonged Mechanical Ventilation in Pediatric Patients with Acute Lung Injury

Table 3

(a) Multivariate results for mortality, excluding patients with sepsis

	Odds ratio (95% C.I.)	P-Value
PaO2/FiO2^1	0.88 (0.79, 0.99)	.03
Other OSF^2	2.28 (1.60, 3.26)	<.01
CNS Failure	6.81 (2.94, 15.79)	<.01
Fluid Balance^3	1.09 (1.00, 1.18)	.05

(b) Multivariate results for ventilator-free days, excluding patients with sepsis

	Coefficient (95% C.I.)	P-Value
PaO2/FiO2^1	0.41 (0.11, 0.70)	<.01
Other OSF^2	−2.92 (−3.98, −1.87)	<.01
CNS failure	−5.56 (−8.55, −2.57)	<.01
Fluid balance^3	−0.21 (−0.42, −0.01)	.04

¹PaO2/FiO2 measured in 20 point increases.
²Nonpulmonary, non-CNS organ system failure.
³Fluid Balance measured in 10 mL/kg/day increment.