Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice

Figure 6

Pulmonary levels tumor necrosis factor alpha (TNF), interleukin (IL)-6, macrophage inflammatory protein (MIP)-2, and keratinocyte-derived chemokine (KC) in lung tissue homogenate in control mice (C) and mice ventilated for 5 hours with lower tidal volumes (L𝑉_𝑇) or higher VT (H𝑉_𝑇). Each group consisted of heterozygote TF knock-out mice (TF^+/−) and their wild-type littermates (TF^+/+). Data represent medians and interquartile range of six mice. *𝑃<0.05 versus TF^+/+ mice.

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