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Critical Care Research and Practice
Volume 2012 (2012), Article ID 173527, 6 pages
http://dx.doi.org/10.1155/2012/173527
Review Article

Failed Weaning from Mechanical Ventilation and Cardiac Dysfunction

1VA Western New York Healthcare System, Division of Critical Care Medicine, Department of Anesthesiology and Medicine, Buffalo School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, NY 14215, USA
2Strong Memorial Hospital, University of Rochester, Rochester, NY 14642, USA
3VA Western New York Healthcare System, Division of Cardiothoracic Anesthesia and Pain Medicine, Department of Anesthesiology, Buffalo School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, NY 14215, USA

Received 20 June 2012; Accepted 3 August 2012

Academic Editor: Zsolt Molnar

Copyright © 2012 Jahan Porhomayon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Failure to transition patient from controlled mechanical ventilation to spontaneous breathing trials (SBTs) in a timely fashion is associated with significant morbidity and mortality in the intensive care unit. In addition, weaning failures are common in patients with limited cardiac reserves. Recent advances in cardiac echocardiography and laboratory measurement of serum biomarkers to assess hemodynamic response to SBT may provide additional information to guide clinicians to predict weaning outcome.