Table of Contents Author Guidelines Submit a Manuscript
Critical Care Research and Practice
Volume 2012, Article ID 182324, 6 pages
http://dx.doi.org/10.1155/2012/182324
Clinical Study

Prediction of Outcome from Community-Acquired Severe Sepsis and Septic Shock in Tertiary-Care University Hospital in a Developing Country

Department of Intensive Care, University Clinic for Infectious Diseases, Vodnjanska 17, 1000 Skopje, Macedonia

Received 21 June 2012; Accepted 20 September 2012

Academic Editor: Djillali Annane

Copyright © 2012 Krsto Grozdanovski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. C. Bone, R. A. Balk, F. B. Cerra et al., “Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine,” Chest, vol. 101, no. 6, pp. 1644–1655, 1992. View at Google Scholar · View at Scopus
  2. M. M. Levy, M. P. Fink, J. C. Marshall et al., “2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference,” Critical Care Medicine, vol. 31, no. 4, pp. 1250–1256, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. D. C. Angus, W. T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo, and M. R. Pinsky, “Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care,” Critical Care Medicine, vol. 29, no. 7, pp. 1303–1310, 2001. View at Google Scholar · View at Scopus
  4. T. Lagu, M. B. Rothberg, M.-S. Shieh, P. S. Pekow, J. S. Steingrub, and P. K. Lindenauer, “Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007,” Critical Care Medicine, vol. 40, no. 3, pp. 754–761, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. J. L. Vincent, Y. Sakr, C. L. Sprung et al., “Sepsis in European intensive care units: results of the SOAP study,” Critical Care Medicine, vol. 34, no. 2, pp. 344–353, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Artero, R. Zaragoza, J. J. Camarena, S. Sancho, R. González, and J. M. Nogueira, “Prognostic factors of mortality in patients with community-acquired bloodstream infection with severe sepsis and septic shock,” Journal of Critical Care, vol. 25, no. 2, pp. 276–281, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Vallés, J. Rello, A. Ochagavía, J. Garnacho, and M. A. Alcalá, “Community-acquired bloodstream infection in critically III adult patients: impact of shock and inappropriate antibiotic therapy on survival,” Chest, vol. 123, no. 5, pp. 1615–1624, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. C. A. Gogos, A. Lekkou, O. Papageorgiou, D. Siagris, A. Skoutelis, and H. P. Bassaris, “Clinical prognostic markers in patients with severe sepsis: a prospective analysis of 139 consecutive cases,” Journal of Infection, vol. 47, no. 4, pp. 300–306, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. J. R. Le Gall, S. Lemeshow, and F. Saulnier, “A new simplified acute physiology score (SAPS II) based on a European/North American multi-center study,” Journal of the American Medical Association, vol. 270, no. 24, pp. 2957–2963, 1993. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Karlsson, M. Varpula, E. Ruokonen et al., “Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the Finnsepsis study,” Intensive Care Medicine, vol. 33, no. 3, pp. 435–443, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Brun-Buisson, P. Meshaka, P. Pinton, and B. Vallet, “EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units,” Intensive Care Medicine, vol. 30, no. 4, pp. 580–588, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Alberti, C. Brun-Buisson, H. Burchardi et al., “Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study,” Intensive Care Medicine, vol. 28, no. 2, pp. 108–121, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. B. Cheng, G. Xie, S. Yao et al., “Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China,” Critical Care Medicine, vol. 35, no. 11, pp. 2538–2546, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. B. Khwannimit and R. Bhurayanontachai, “The epidemiology of, and risk factors for, mortality from severe sepsis and septic shock in a tertiary-care university hospital setting,” Epidemiology and Infection, vol. 137, no. 9, pp. 1333–1341, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Rodríguez, L. Barrera, G. De La Rosa et al., “The epidemiology of sepsis in Colombia: a prospective multicenter cohort study in ten university hospitals,” Critical Care Medicine, vol. 39, no. 7, pp. 1675–1682, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Cardoso, A. H. Carneiro, O. Ribeiro, A. Teixeira-Pinto, and A. Costa-Pereira, “Reducing mortality in severe sepsis with the implementation of a core 6-hour bundle: results from the Portuguese community-acquired sepsis study (SACiUCI study),” Critical Care, vol. 14, no. 3, article R83, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. M. W. Wichmann, D. Inthorn, H. J. Andress, and F. W. Schildberg, “Incidence and mortality of severe sepsis in surgical intensive care patients: the influence of patient gender on disease process and outcome,” Intensive Care Medicine, vol. 26, no. 2, pp. 167–172, 2000. View at Google Scholar · View at Scopus
  18. G. S. Martin, D. M. Mannino, and M. Moss, “The effect of age on the development and outcome of adult sepsis,” Critical Care Medicine, vol. 34, no. 1, pp. 15–21, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Alberti, C. Brun-Buisson, S. V. Goodman et al., “Influence of systemic inflammatory response syndrome and sepsis on outcome of critically III infected patients,” American Journal of Respiratory and Critical Care Medicine, vol. 168, no. 1, pp. 77–84, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. M. D. Tanriover, G. S. Guven, D. Sen, S. Unal, and O. Uzun, “Epidemiology and outcome of sepsis in a tertiary-care hospital in a developing country,” Epidemiology and Infection, vol. 134, no. 2, pp. 315–322, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Blanco, A. Muriel-Bombín, V. Sagredo et al., “Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study,” Critical Care, vol. 12, no. 6, article R158, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. J.-R. Zahar, J.-F. Timsit, M. Garrouste-Orgeas et al., “Outcomes in severe sepsis and patients with septic shock: pathogen species and infection sites are not associated with mortality,” Critical Care Medicine, vol. 39, no. 8, pp. 1886–1895, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. R. P. Dellinger, M. M. Levy, J. M. Carlet et al., “Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008,” Critical Care Medicine, vol. 36, no. 1, pp. 296–327, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. M. M. Levy, R. P. Dellinger, S. R. Townsend et al., “The surviving sepsis campaign: results of an international guideline-based performance improvement program targeting severe sepsis,” Critical Care Medicine, vol. 38, no. 2, pp. 367–374, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Y. Lefrant, L. Muller, A. Raillard et al., “Reduction of the severe sepsis or septic shock associated mortality by reinforcement of the recommendations bundle: a multicenter study,” Annales Francaises d'Anesthesie et de Reanimation, vol. 29, no. 9, pp. 621–628, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. J. L. Vincent, J. Rello, J. Marshall et al., “International study of the prevalence and outcomes of infection in intensive care units,” Journal of the American Medical Association, vol. 302, no. 21, pp. 2323–2329, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. B. Guidet, P. Aegerter, R. Gauzit, P. Meshaka, and D. Dreyfuss, “Incidence and impact of organ dysfunctions associated with sepsis,” Chest, vol. 127, no. 3, pp. 942–951, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Routsi, M. Pratikaki, C. Sotiropoulou et al., “Application of the sequential organ failure assessment (SOFA) score to bacteremic ICU patients,” Infection, vol. 35, no. 4, pp. 240–244, 2007. View at Publisher · View at Google Scholar · View at Scopus