Stimulators and Activators of Soluble Guanylate Cyclase: Review and Potential Therapeutic Indications

<table>Role of NO (nitric oxide), inhaled NO, and sGC (soluble guanylyl cyclase) stimulators in stimulating the reduced heme of sGC and the role of sGC activators in stimulated oxidized sGC to stimulate cGMP leading to vasodilation, inhibition of platelet aggregation and an anti-inflammatory effect in the vascular bed.</table>

Critical Care Research and Practice

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Figure 2

Figure 2: Stimulators and Activators of Soluble Guanylate Cyclase: Review and Potential Therapeutic Indications 