Manipulation of the Complement System for Benefit in Sepsis

Table 1

Survival of k. o. mice after CLP.

Grade of CLP	Genotype	Time after CLP	Survival
High grade*	Wt	Day 3	0%
High grade	C5aR^−/−	Day 3	85%
High grade	C5L2^−/−	Day 3	80%
Intermediate grade**	Wt	Day 7	31%
Intermediate grade	C3^−/−	Day 7	5%
Intermediate grade	C5^−/−	Day 7	15%
Intermediate grade	C5aR^−/−	Day 7	80%
Intermediate grade	C5L2^−/−	Day 7	100%

^{*, **}Grades as defined in [2, 4].