Manipulation of the Complement System for Benefit in Sepsis

Table 4

Activation of caspases in thymocytes after CLP.

Caspase	Treatment*
	Normal IgG	Anti-C5a IgG
3	3.72	1.75
6	3.0	1.63
8	No change	No change
9	2.85	1.15

*Expressed as fold increase in thymocytes 12 hr after CLP. A fold change of 1.0 would represent no change in caspase activity. Caspase activity was expressed as release (pg/μg protein) of the fluorogenic substrate 7-amino-4-tri-fluoromethyl coumarin (AFC) as described in [20].