Consecutive Daily Measurements of Luminal Concentrations of Lactate in the Rectum in Septic Shock Patients
Table 2
Daily parameters in 22 patients with septic shock stratified by survival.
Nonsurvivors
Survivors
Day 1
Day 2
Day 3
Day 1
Day 2
Day 3
Heart rate (bpm)
94
92
80
90
90
88
(88–114)
(80–125)
(70–95)a
(82–96)
(75–107)
(81–104)
Sinus rhythm
5/5
4/5
3/3
14/17
12/17
10/12
Atrial fibrillation
0/5
1/5
0/3
3/17
5/17
2/12
MAP (mmHg)
76
85
75
74
79
82
(67–80)
(78–94)
(73–108)a
(70–79)
(75–85)
(71–92)
Noradrenaline dose
0.34
0.04
0.00
0.12
0.06
0.00
(μg/kg/min)
(0.12–0.49)
(0.01–0.09)
(0.00–0.03)a
(0.09–0.16)
(0.00–0.22)
(0.00–0.15)
ScvO2 (%)
79
78
73
74
76
76
(73–84)
(75–80)
(62–76)a
(68–80)
(70–80)
(72–80)
IAP (mmHg)
14
16#
12
12
13
12
(11–16)
(15–17)
(11–14)a
(11–15)
(9–15)
(8–17)
Lactate, arterial
1.9
1.5
1.4
1.8
2.0
1.4
(mmol/L)
(1.6–8.2)
(1.2–3.7)
(1.4–3.4)a
(1.4–3.4)
(1.3–2.6)
(1.1–2.2)
Lactate, rectal lumen
2.4
3.2
2.9
2.1
2.1
2.3
(mmol/ L)
(1.3–7.5)
(1.7–4.2)
(1.5–3.0)a
(1.2–4.4)
(1.1–3.4)
(0.9–3.0)
Delta-lactate
−0.25
0.60
0.20
0.45
−0.10
0.30
(rectal-arterial (mmol/ L))
(−1.0–0.3)
(−0.4–2.0)
(−0.5–1.7)
(−0.5–1.2)
(−1.1–2.0)
(−0.4–1.3)
Values are medians (25th–75th percentiles). #P = 0.02 compared with IAP day 2 in survivors. No other significant differenceswere found using the Mann Whitney test (comparing values between groups on specific days) or Wilcoxon’s signed rank test or Friedmans’s test (comparing paired values within groups over 2 or 3 days, resp.). since .
