Persistent Sepsis-Induced Hypotension without Hyperlactatemia: A Distinct Clinical and Physiological Profile within the Spectrum of Septic Shock
Table 1
General characteristics of the cohort and subgroups of patients.
Total
Lactate < 2.5
Lactate ≥ 2.5
Number of patients
124
38
86
Age (y)
65 [53–75]
62 [39–73]
65 [58–75]
ICU LOS (d)
5 [3–9]
4.5 [2–7]
5 [3–10]
APACHE II score
18 [12–24]
12 [8–19]
20 [15–25]**
Basal SOFA score
8 [5–10]
6 [3–8]
9 [6–11]**
ICU mortality (%)
13.7
5.2
Hospital mortality (%)
17.6
7.9
Patients in MV (%)
79
71
Length of MV (d)
2 [1–5]
1 [0–3.7]
3 [1–7]*
Renal replacement therapy
19
3
16*
Sepsis source (%)
Pulmonary
27
26
28
Abdominal
45
45
44
Other
28
29
28
Adequate initial AB empiric coverage (%)
Yes
81
71
85
No
13
16
12
Unknown
6
13
3
Comorbidities (%)
Diabetes
20
19
21
Hypertension
26
23
27
Chronic kidney disease
7
6
8
Stroke
24
0
3
Atrial fibrillation
11
0
15
*
for the comparison between subgroups.
**
for the comparison between subgroups. Data are shown as median [interquartile range] or percentage. ICU: intensive care unit; LOS: length of stay; APACHE: acute physiology and chronic health evaluation; SOFA: sequential organ failure assessment; MV: mechanical ventilation; AB: antibiotic.
