Persistent Sepsis-Induced Hypotension without Hyperlactatemia: A Distinct Clinical and Physiological Profile within the Spectrum of Septic Shock

Table 2

Baseline and peak laboratory parameters of organ dysfunction.

	Lactate < 2.5 mmol/l	Lactate ≥ 2.5 mmol/l
Baseline PaO2/FiO2	260 [185–388]	275 [160–339]
Lowest PaO2/FiO2	257 [184–340]	218 [150–286]
Baseline D-dimer levels (ng/mL)	3070 [2031–4198]	3788 [2096–5480]
Peak D-dimer levels (ng/mL)	3447 [2182–4771]	5298 [2885–7392]
Baseline platelet count (×10^3/mm^3)	192 [157–332]	145 [101–255]*
Lowest platelet count (×10^3/mm^3)	171 [116–261]	83.5 [43.3–162.5]**
Baseline bilirubin levels (mg/dL)	0.7 [0.5–1.3]	1 [0.6–1.9]
Peak bilirubin levels (mg/dl)	0.7 [0.6–1.7]	1.1 [0.7–3]
Baseline C-reactive protein levels (mg/dL)	15.9 [8.5–25.9]	14.7 [5.7–27.6]
Peak C-reactive protein levels (mg/dL)	24.4 [15.2–33.9]	28 [19.7–36]
Baseline serum creatinine levels (mg/dL)	0.8 [0.6–1.6]	1.7 [1–3]**
Peak serum creatinine levels (mg/dL)	1 [0.6–1.7]	1.7 [1.1–2.9]**

* 𝑃<0.05.
** 𝑃<0.01.
Data are shown as median [interquartile range].