Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis

<table>Multiple roles of TM in the maintenance of vascular homeostasis. TM inhibits inflammation, apoptosis, tumor metastasis, thrombin function, adhesion molecule expression, and leukocyte adhesion. Proinflammatory high-mobility group box 1 (HMGB1) is neutralized and degraded by TM.</table>

Critical Care Research and Practice

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Figure 2: Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis 