Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis

Figure 3

Structure and domains of TM. TM contains an N-terminal C-type lectin-like domain, an extended stalk of six EGF modules, a serine/threonine-rich region with target sites for posttranslational glycosylation, a transmembrane domain, and a short cytoplasmic domain. EGF domains 5-6 bind thrombin. EGF4-6 is required for protein C activation and EGF3-6 for TAFI activation.