Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis

Figure 5

TAFIa-dependent modulation of inflammation and fibrinolysis. TAFIa appears to possess anti-inflammatory properties due to its ability to inactivate proinflammatory mediators, C3a, C5a, bradykinin, and osteopontin by removing their C-terminal residues. TAFIa also removes the C-terminal lysines of fibrin, leading to a reduction in the rates of plasmin generation and fibrinolysis. PF4 inhibits the activation of TAFI and enhances the activation of protein C by the TM-thrombin complex.