Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis

<table>APC- and TAFIa-independent anti-inflammatory effects of TM. Thrombomodulin binds to thrombin, thereby blocking activation of protease-activated receptors. The lectin-like domain binds to, and enhances degradation of, proinflammatory molecule HMGB1. In addition, the lectin-like domain is thought to bind to an unidentified receptor, thereby suppressing MAP kinase and NF-<svg height="7.9499998" id="M5" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 8.7375002 7.9499998" width="8.7375002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,0,0,-.017,.062,7.675)"><path d="M484 406q0 -21 -22 -38q-10 -7 -18 -1q-15 11 -30 11q-30 0 -77.5 -37t-74.5 -67l79 -168q11 -23 19.5 -34.5t13 -14t10.5 -2.5q9 0 30 17.5t40 42.5l17 -23q-31 -45 -57.5 -69.5t-40.5 -29.5t-31 -5q-18 0 -32 13.5t-35 55.5q-34 71 -69 160q-36 -32 -59 -56
q-12 -27 -36 -158q-44 -7 -77 -15l-5 7l82 349q6 25 -2 25q-16 0 -72 -41l-14 22q44 41 89 69.5t66 28.5q19 0 19 -32q0 -16 -6 -43l-35 -160l146 143q94 92 136 92q20 0 33 -12t13 -30z" id="x1D705"></path></g>
</svg>B activation.</table>

Critical Care Research and Practice

fig6

Figure 6

Figure 6: Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis 