Table of Contents Author Guidelines Submit a Manuscript
Critical Care Research and Practice
Volume 2012, Article ID 712695, 8 pages
http://dx.doi.org/10.1155/2012/712695
Clinical Study

Systemic and Urinary Neutrophil Gelatinase-Associated Lipocalins Are Poor Predictors of Acute Kidney Injury in Unselected Critically Ill Patients

1Department of Intensive Care Medicine, Tergooi Hospitals, Location Blaricum, 1261 AN Blaricum, The Netherlands
2Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
3Laboratory for Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
4Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
5Department of Intensive Care Medicine, Scheper Ziekenhuis Emmen, 7824 AA Emmen, The Netherlands
6Department of Intensive Care Medicine, Medical Center Leeuwarden, 8934 AD Leeuwarden, The Netherlands
7HERMES Critical Care Group, 1105 AZ Amsterdam, The Netherlands
8Department of Intensive Care Medicine, Gelre Hospitals, Location Lucas, 7334 DZ Apeldoorn, The Netherlands

Received 11 June 2012; Accepted 19 September 2012

Academic Editor: Manuel E. Herrera-Gutiérrez

Copyright © 2012 Annick A. Royakkers et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Andrikos, P. Tseke, O. Balafa et al., “Epidemiology of acute renal failure in ICUs: a multi-center prospective study,” Blood Purification, vol. 28, no. 3, pp. 239–244, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Kes and N. B. Jukic, “Acute kidney injury in the intensive care unit,” Bosnian Journal of Basic Medical Sciences, vol. 10, supplement 1, pp. S8–12, 2010. View at Google Scholar
  3. N. V. Kolhe, P. E. Stevens, A. V. Crowe, G. W. Lipkin, and D. A. Harrison, “Case mix, outcome and activity for patients with severe acute kidney injury during the first 24 hours after admission to an adult, general critical care unit: application of predictive models from a secondary analysis of the ICNARC Case Mix Programme Database,” Critical Care, vol. 12, supplement 1, p. S2, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Uchino, J. A. Kellum, R. Bellomo et al., “Acute renal failure in critically ill patients: a multinational, multicenter study,” Journal of the American Medical Association, vol. 294, no. 7, pp. 813–818, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. W. Y. Park, E. A. Hwang, M. H. Jang, S. B. Park, and H. C. Kim, “The risk factors and outcome of acute kidney injury in the intensive care units,” Korean Journal of Internal Medicine, vol. 25, no. 2, pp. 181–187, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. P. Devarajan, “Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 68, supplement 241, pp. 89–94, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Devarajan, J. Mishra, S. Supavekin, L. T. Patterson, and S. S. Potter, “Gene expression in early ischemic renal injury: clues towards pathogenesis, biomarker discovery, and novel therapeutics,” Molecular Genetics and Metabolism, vol. 80, no. 4, pp. 365–376, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. K. M. Schmidt-Ott, K. Mori, Y. L. Jau et al., “Dual action of neutrophil gelatinase-associated lipocalin,” Journal of the American Society of Nephrology, vol. 18, no. 2, pp. 407–413, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Haase, R. Bellomo, P. Devarajan, P. Schlattmann, and A. Haase-Fielitz, “Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis,” American Journal of Kidney Diseases, vol. 54, no. 6, pp. 1012–1024, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. J. L. Koyner, M. R. Bennett, E. M. Worcester et al., “Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery,” Kidney International, vol. 74, no. 8, pp. 1059–1069, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Mishra, C. Dent, R. Tarabishi et al., “Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery,” The Lancet, vol. 365, no. 9466, pp. 1231–1238, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. V. S. Vaidya, S. S. Waikar, M. A. Ferguson et al., “Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans,” Clinical and Translational Science, vol. 1, no. 3, pp. 200–208, 2008. View at Publisher · View at Google Scholar
  13. R. Bellomo, C. Ronco, J. A. Kellum, R. L. Mehta, and P. Palevsky, “Acute renal failure-definition, outcome measures, animal models, fluid therapy and information technology needs: the second international consensus conference of the acute dialysis quality initiative (ADQI) group,” Critical Care, vol. 8, no. 4, pp. R204–212, 2004. View at Google Scholar · View at Scopus
  14. A. A. N. M. Royakkers, J. C. Korevaar, J. D. E. Van Suijlen et al., “Serum and urine cystatin C are poor biomarkers for acute kidney injury and renal replacement therapy,” Intensive Care Medicine, vol. 37, no. 3, pp. 493–501, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. W. A. Knaus, E. A. Draper, D. P. Wagner, and J. E. Zimmerman, “APACHE II: a severity of disease classification system,” Critical Care Medicine, vol. 13, no. 10, pp. 818–829, 1985. View at Google Scholar · View at Scopus
  16. J. R. Le Gall, S. Lemeshow, and F. Saulnier, “A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study,” Journal of the American Medical Association, vol. 270, no. 24, pp. 2957–2963, 1993. View at Publisher · View at Google Scholar · View at Scopus
  17. A. S. Levey, J. P. Bosch, J. B. Lewis, T. Greene, N. Rogers, and D. Roth, “A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation,” Annals of Internal Medicine, vol. 130, no. 6, pp. 461–470, 1999. View at Google Scholar · View at Scopus
  18. B. Z. Morgenstern, L. Butani, P. Wollan, D. M. Wilson, and T. S. Larson, “Validity of protein-osmolality versus protein-creatinine ratios in the estimation of quantitative proteinuria from random samples of urine in children,” American Journal of Kidney Diseases, vol. 41, no. 4, pp. 760–766, 2003. View at Google Scholar · View at Scopus
  19. S. M. Bagshaw, M. Bennett, M. Haase et al., “Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness,” Intensive Care Medicine, vol. 36, no. 3, pp. 452–461, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. E. D. Siew, M. E. Matheny, T. A. Ikizler et al., “Commonly used surrogates for baseline renal function affect the classification and prognosis of acute kidney injury,” Kidney International, vol. 77, no. 6, pp. 536–542, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Prabhu, D. I. Sujatha, B. Ninan, and M. A. Vijayalakshmi, “Neutrophil gelatinase associated lipocalin as a biomarker for acute kidney injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass,” Annals of Vascular Surgery, vol. 24, no. 4, pp. 525–531, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Wagener, M. Jan, M. Kim et al., “Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery,” Anesthesiology, vol. 105, no. 3, pp. 485–491, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. C. L. Dent, Q. Ma, S. Dastrala et al., “Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study,” Critical Care, vol. 11, no. 6, p. R127, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Xin, X. Yulong, C. Yu, C. Changchun, Z. Feng, and M. Xinwei, “Urine neutrophil gelatinase-associated lipocalin and interleukin-18 predict acute kidney injury after cardiac surgery,” Renal Failure, vol. 30, no. 9, pp. 904–913, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Bennett, C. L. Dent, Q. Ma et al., “Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study,” Clinical Journal of the American Society of Nephrology, vol. 3, no. 3, pp. 665–673, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. F. Capuano, M. Goracci, R. Luciani et al., “Neutrophil gelatinase-associated lipocalin levels after use of mini-cardiopulmonary bypass system,” Interactive Cardiovascular and Thoracic Surgery, vol. 9, no. 5, pp. 797–801, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. S. M. Tuladhar, V. O. Püntmann, M. Soni, P. P. Punjabi, and R. G. Bogle, “Rapid detection of acute kidney injury by plasma and urinary neutrophil gelatinase-associated lipocalin after cardiopulmonary bypass,” Journal of Cardiovascular Pharmacology, vol. 53, no. 3, pp. 261–266, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Makris, N. Markou, E. Evodia et al., “Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients,” Clinical Chemistry and Laboratory Medicine, vol. 47, no. 1, pp. 79–82, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Zappitelli, K. K. Washburn, A. A. Arikan et al., “Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study,” Critical Care, vol. 11, p. R84, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. D. S. Wheeler, P. Devarajan, Q. Ma et al., “Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock,” Critical Care Medicine, vol. 36, no. 4, pp. 1297–1303, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. D. N. Cruz, M. De Cal, F. Garzotto et al., “Plasma neutrophil gelatinase-associated lipocalin is an early biomarker for acute kidney injury in an adult ICU population,” Intensive Care Medicine, vol. 36, no. 3, pp. 444–451, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. J. M. Constantin, E. Futier, S. Perbet et al., “Plasma neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in adult critically ill patients: a prospective study,” Journal of Critical Care, vol. 25, no. 1, pp. 176–e1, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. H. R. H. de Geus, J. Bakker, E. M. E. H. Lesaffre, and J. L. M. L. Le Noble, “Neutrophil gelatinase-associated lipocalin at ICU admission predicts for acute kidney injury in adult patients,” American Journal of Respiratory and Critical Care Medicine, vol. 183, no. 7, pp. 907–914, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Mårtensson, M. Bell, A. Oldner, S. Xu, P. Venge, and C. R. Martling, “Neutrophil gelatinase-associated lipocalin in adult septic patients with and without acute kidney injury,” Intensive Care Medicine, vol. 36, no. 8, pp. 1333–1340, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. K. Mori, H. T. Lee, D. Rapoport et al., “Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury,” Journal of Clinical Investigation, vol. 115, no. 3, pp. 610–621, 2005. View at Publisher · View at Google Scholar · View at Scopus