Research Article
Mechanical Ventilation and the Titer of Antibodies as Risk Factors for the Development of Transfusion-Related Lung Injury
Figure 2
Histologic sections of hematoxylin-and-eosin-stained mice lungs at 100x magnification after mechanical ventilated using low ventilation tidal (VT) (7.5 mL/kg) or high VT (15 mL/kg). Ventilated animals receiving 0.5 mg/kg, 2.0 mg/kg or 4.5 mg/kg MHC-I antibody ( per group). (a) low VT control, (b) high VT control, (c) 0.5 mg/kg low VT, (d) 0.5 mg/kg high VT, (e) 2.0 mg/kg low VT, (f) 2.0 mg/kg high VT, (g) 4.5 mg/kg low VT, (h) 4.5 mg/kg high VT. Neutrophils sequestrated in the vasculature (arrow; (a)–(h)). Increased pulmonary edema and neutrophil extravasation ((d), (f)–(h)).
