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Critical Care Research and Practice
Volume 2012, Article ID 856401, 5 pages
Research Article

Sepsis and AKI in ICU Patients: The Role of Plasma Biomarkers

1Department of Nephrology, San Bassiano Hospital, 36061 Bassano del Grappa, Italy
2Division of Nephrology, University of Padua, 35100 Padua, Italy
3Department of Nephrology, San Bortolo Hospital, 36100 Vicenza, Italy

Received 3 August 2011; Revised 6 October 2011; Accepted 22 November 2011

Academic Editor: Alain Broccard

Copyright © 2012 Paolo Lentini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Given the higher mortality rate of ICU patients with sepsis and AKI, we decided to investigate the possible correlation between serum biomarkers of organ damage, and endotoxin activity in ICU septic patients. Ninety-eight consecutive adult patients were enrolled in this study. Patients were divided in two groups depending on the presence of sepsis. Fifty-six patients had sepsis, while forty-two patients were nonseptic. Among septic patients, twenty-four subjects developed AKI, while thirty-two did not. AKI occurred in fourteen patients without sepsis as well. The levels of NGAL, BNP, and AOPP were significantly higher among septic patients compared with nonseptic subjects ( ). Among septic patients, subjects who developed AKI showed significant higher levels of NGAL and AOPP ( ) and BNP ( ). Among patients who developed AKI, a significant difference was found only in terms of AOPP levels between septic and nonseptic patients. The correlation between endotoxin activity and BNP in septic patients and the increase in the levels of NGAL, BNP, and AOPP in case of sepsis and AKI, in particular if they are associated, indicate a multiorgan involvement in these two conditions.