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Critical Care Research and Practice
Volume 2012, Article ID 896430, 9 pages
Review Article

Myocardial Dysfunction in Sepsis: A Large, Unsolved Puzzle

1Hospital Israelita Albert Einstein, Avenida Albert Einstein 627/701, 05661-901 Morumbi, SP, Brazil
2Department of Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil

Received 16 October 2011; Revised 14 December 2011; Accepted 4 January 2012

Academic Editor: D. Annane

Copyright © 2012 Constantino Jose Fernandes Jr. and Murillo Santucci Cesar de Assuncao. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Sepsis has high incidence and mortality rates around the world. The role of cardiac depression in myocardial dysfunction during sepsis remains to be elucidated. This review attempts to summarize our understanding of the anatomical, histopathological, and pathophysiological mechanisms behind cardiac dysfunction. Biomarkers to detect cardiac depression have been used to recognize developing problems, but the actual impact of these tools remains unclear.