Role of New Biomarkers: Functional and Structural Damage

Table 1

NGAL for prediction of AKI after cardiac surgery.

Reference	Publication year	No. of AKI pts	Type of NGAL	Sensitivity (%)	Specificity (%)	AUC-ROC
Mishra et al. [9]*	2005	20/71	pNGAL; uNGAL	70.0; 100.0	94.1; 98.0	0.91; 0.99
Wagener et al. [10]	2006	16/81	uNGAL	68.8	64.6	0.73
Dent et al. [11]*	2007	45/123	pNGAL	84.4	93.6	0.96
Wagener et al. [12]	2008	68/426	uNGAL	64.7	52.0	0.64
Bennett et al. [13]*	2008	99/196	uNGAL	78.8	91.8	0.95
Xin et al. [14]	2008	9/36	uNGAL	76.9	70.4	0.86
Koyner et al. [15]	2008	21/72; 21/72	pNGAL; uNGAL	44.4; 66.7	75.9; 64.8	0.56; 0.68
Tuladhar et al. [16]	2009	9/50; 9/50	pNGAL; uNGAL	77.8; 88.9	68.3; 78.1	0.80; 0.96
Haase-Fielitz et al. [17]	2009	23/100	sNGAL	78.3	77.9	0.80
Che et al. [18]	2010	14/29	uNGAL	84.0	80.0	0.85
Prabhu et al. [19]	2010	8/30	pNGAL	—	—	0.98
Perry et al. [20]	2010	75/879	pNGAL	38.7	81.5	0.64
Krawczeski et al. [21]*	2011	60/220	uNGAL	—	—	0.90
Parikh et al. [22]	2011	60/1219	uNGAL; pNGAL	46; 50	81; 82	0.67; 0.70
Fadel et al. [23]*	2012	19/40	pNGAL	100	90.5	0.95
Liu et al. [24]	2012	26/109	uNGAL	81.8	83.1	0.87

*Pediatric population, uNGAL: urine NGAL, pNGAL: plasma NGAL, sNGAL: serum NGAL, and AUC-ROC: area under the receiver-operating characteristic curve, —: not mentioned by the authors.