Critical Care Research and Practice / 2013 / Article / Tab 2 / Review Article
Role of New Biomarkers: Functional and Structural Damage Table 2 NGAL for prediction of AKI in mixed ICU patients.
Reference Publication year No. of AKI pts Type of NGAL Sensitivity (%) Specificity (%) AUC-ROC Zappitelli et al. [25 ]* 2007 16/39 uNGAL 75.0 69.6 0.76 Wheeler et al. [26 ]* 2008 22/143 sNGAL 86.4 38.8 0.68 Makris et al. [27 ] 2009 7/31 uNGAL 85.7 70.8 0.90 Siew et al. [28 ] 2009 86/451 uNGAL 60.0 80.0 0.71 Little et al. [29 ] 2009 161/604 uNGAL pNGAL 43.0 64.0 90.0 90.0 0.84 0.83 Cruz et al. [30 ] 2010 15/301 pNGAL 73.4 80.6 0.78 Shapiro et al. [31 ] 2010 13/558 pNGAL 78.0 80.0 0.84 Mårtensson et al. [32 ] 2010 18/45 uNGAL pNGAL 71.0 83.0 100.0 86.0 0.86 0.67 Constantin et al. [33 ] 2010 52/88 pNGAL 82.7 97.2 0.93 de Geus et al. [34 ] 2011 171/632 uNGAL pNGAL 89.0 82.0 70.0 70.0 0.80 0.77 Royakkers et al. [35 ] 2012 83/140 uNGAL sNGAL — — — — 0.48 0.53
*Pediatric population, uNGAL: urine NGAL, pNGAL: plasma NGAL, sNGAL: serum NGAL, and AUC-ROC: area under the receiver-operating characteristic curve, —: not mentioned by the authors.