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Critical Care Research and Practice
Volume 2013, Article ID 856747, 9 pages
Clinical Study

Is Vitamin D Insufficiency Associated with Mortality of Critically Ill Patients?

1Division of Critical Care Medicine, Department of Internal Medicine, Gazi University Faculty of Medicine, Besevler, 06510 Ankara, Turkey
2Department of Medical Biochemistry, Gazi University Faculty of Medicine, Besevler, 06510 Ankara, Turkey

Received 9 August 2013; Revised 28 September 2013; Accepted 13 October 2013

Academic Editor: Stephen M. Pastores

Copyright © 2013 Gulbin Aygencel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To evaluate the vitamin D status of our critically ill patients and its relevance to mortality. Patients and Methods. We performed a prospective observational study in the medical intensive care unit of a university hospital between October 2009 and March 2011. Vitamin D levels were measured and insufficiency was defined as <20 ng/mL. Results. Two hundred and one patients were included in the study. The median age was 66 (56–77) and the majority of patients were male (56%). The median serum level of vitamin D was 14,9 ng/mL and 139 (69%) patients were vitamin D insufficient on admission. While we grouped the ICU patients as vitamin D insufficient and sufficient, vitamin D insufficient patients had more severe acute diseases and worse laboratory values on admission. These patients had more morbidities and were exposed to more invasive therapies during stay. The mortality rate was significantly higher in the vitamin D insufficient group compared to the vitamin D sufficient group (43% versus 26%, ). However, logistic regression analysis demonstrated that vitamin D insufficiency was not an independent risk factor for mortality. Conclusion. Vitamin D insufficiency is common in our critically ill patients (69%), but it is not an independent risk factor for mortality.