An In Vitro Analysis of the Effects of Intravenous Lipid Emulsion on Free and Total Local Anaesthetic Concentrations in Human Blood and Plasma

Table 1

Summary of local anaesthetic concentrations utilised in this study and pharmacokinetic properties of the various agents used.

Local; anaesthetic	Concentrations; utilised; (mg/L)	(lipid partition coefficient)	pKa	Protein; binding; (%)	Volume of; distribution; (L/kg)
Prilocaine	4, 7	2.1	7	50	0.7–4.4
Lignocaine	4, 14	2.4	7.9	70	1-2
Ropivacaine	4, 6	2.9	8.16	94	41–59
Bupivacaine	4	3.4	8.1	90	1