Dose-Dependent Hemodynamic, Biochemical, and Tissue Oxygen Effects of OC99 following Severe Oxygen Debt Produced by Hemorrhagic Shock in Dogs

Table 1

Comparison of composition of OC99 (Oxapex), HBOC-301 (Oxyglobin), and HBOC-201 (Hemopure).

	OC99 (Oxapex)	HBOC-301 (Oxyglobin)	HBOC-201 (Hemopure)
Hemoglobin concentration (g/dL)	6-7	12–14	12–14
Met-hemoglobin (%)	≤5%	<10	<10
P50 (mmHg)	39	40	40
pH	7.2–7.6	7.6–7.9	7.6–7.9
Endotoxin (EU/mL)	<0.05	<0.5	<0.5
Phospholipid (nmol/mL)	nd	<3	<3
Colloid osmotic pressure (mmHg)	19	42	25
Osmolarity (mOsm/kg)	250–350	300	300
Tetrameric hemoglobin (%)	>85	≤35	≤2
Average molecular weight (kDa)	65	200	250
Viscosity (centripoise at 37°C)	1.1	1.3	1.3
Half-life in humans/animals (hours)	16–55*	18–43	19
Cross-linking agent	bis (3,5-dibromosalicyl) fumarate.	gluteraldehyde	gluteraldehyde
Storage conditions (°C)	<25 (without freezing)	2–30	2–30

Dose dependent; nd: nondetectable.