Critical Care Research and Practice

Research Article

Dose-Dependent Hemodynamic, Biochemical, and Tissue Oxygen Effects of OC99 following Severe Oxygen Debt Produced by Hemorrhagic Shock in Dogs

Table 2

Representative systemic/left-ventricular hemodynamic, mechanical, and metabolic parameters measured before (i.e., at baseline) and after the induction of shock/oxygen imbalance via controlled hemorrhage in the isoflurane anesthetized closed-chest canine preparation.
Model characteristics ()
Parameter (units)BaselineHemorrhagic shock5
Hematocrit, PCV (%)441.9 (1.2)40.5 (0.9)
Total Hb (g/dL)14.3 (0.4)13.8 (0.3)
Plasma Hb (g/dL)0.06 (0.01)0.07 (0.01)
MAP (mmHg)105 (3)40 (1)*
SVR (dyne/cm/s−5)4,192 (121)7,053 (305)*
PAP (mmHg)20.4 (0.6)14.6 (0.5)*
PVR (dyne/cm/s−5)471 (18)2,584 (199)*
HR (bpm)131 (4)212 (5)*
LV-dP/dtmax (mmHg/s)1+2,249 (85)+1,214 (52)*
LV-dP/dtmin (mmHg/s)1−2,152 (82)−822 (42)*
Cardiac output (L/min)21.9 (0.1)0.4 (0.0)*
Oxygen extraction ratio (%)12.8 (0.9)67.6 (1.2)*
PaO2 (mmHg)82.5 (1.5)86.4 (1.4)*
PaCO2 (mmHg)38.9 (0.6)27.9 (0.9)*
tPO2 (mmHg)332.2 (1.6)2.7 (0.6)*
pHa7.30 (0.01)7.19 (0.01)*
BE (mM/L)4−7.2 (0.4)−17.5 (0.6)*
LA (mM/L)42.2 (0.1)7.2 (0.2)*
SvO2 (%)82.6 (0.9)30.4 (1.1)*
Data are mean values (standard error of the mean).
Derived from left-ventricular pressure (LVP) signals.
Measured/derived via thermodilution.
Measured directly via optical fluorescence in the intestine.
Measured/derived from arterial blood samples.
The average volume of blood shed during the hemorrhagic shock period was 644 ± 18 mL.
(statistically significant) versus baseline.