Critical Care Research and Practice

Research Article

Dose-Dependent Hemodynamic, Biochemical, and Tissue Oxygen Effects of OC99 following Severe Oxygen Debt Produced by Hemorrhagic Shock in Dogs

Table 3

Summary analysis: mean values (with standard errors) for each treatment group both prior to (SHOCK) and at the end of treatment (END-DOSE), 1 (+1hr) and 2 hours after the end of the experiment (END). (a) Data for HEX + CTRL, HEX + LOW, and HEX + MID. (b) Data for HEX + CTRL and HEX + HIGH.

(a)

Parameter (units)

HEX + CTRL

HEX + LOW

HEX + MID

Shock

End-dose

+1hr

End

Shock

End-dose

+1hr

End

Shock

End-dose

+1hr

End

PCV (%)

39.5 (1.3)

21.3 (1.7)^†

21.3 (1.4)^†

19.9 (1.4)^†

39.3 (1.8)

20.3 (0.6)^†

19.4 (0.9)^†

19.9 (1.0)^†

42.5 (2.8)

20.8 (0.9)^†

20.3 (1.1)^†

21.2 (1.3)^†

Total Hb (g/dL)

13.5 (0.4)

7.3 (0.6)^†

7.3 (0.5)^†

6.8 (0.5)^†

13.5 (0.6)

7.1 (0.2)^†

6.7 (0.3)^†

6.9 (0.3)^†

14.5 (0.9)

7.7 (0.3)^†

7.5 (0.4)^†

7.7 (0.5)^†

Plasma Hb (g/dL)

0.06 (0.01)

0.03 (0.01)^†

0.07 (0.02)

0.15 (0.00)^*†

0.14 (0.01)^*†

0.14 (0.00)^*†

0.07 (0.01)

0.63 (0.01)^*†

0.59 (0.02)*

0.53 (0.02)^*†

MAP (mmHg)

41.7 (2.3)

90.3 (6.7)^†

84.7 (7.0)^†

63.1 (7.3)^†

36.9 (1.2)

96.1 (4.1)

79.3 (7.0)^†

56.3 (5.1)^†

41.5 (0.9)

114.3 (6.3)*

107.2 (9.3)*

89.3 (8.3)

PAP (mmHg)

14.4 (0.6)

20.3 (1.9)

17.3 (1.7)^†

16.8 (1.7)^†

15.2 (1.4)

21.7 (2.0)

17.0 (1.4)

16.0 (1.2)^†

14.7 (0.8)

22.4 (1.5)

17.5 (0.9)

16.1 (1.2)^†

HR (bpm)

195.7 (10.0)

187.6 (8.3)^†

196.9 (9.6)^†

209.6 (10.0)^†

213.1 (7.7)

200.3 (6.7)^†

203.4 (6.9)^†

196.5 (4.1)^†

228.5 (6.3)

204.6 (6.2)^†

203.0 (8.2)^†

201.5 (8.2)^†

CO (L/min)

0.4 (0.0)

1.8 (0.1)

1.4 (0.1)

1.0 (0.1)^†

0.4 (0.1)

1.9 (0.1)

1.3 (0.1)^†

1.0 (0.1)^†

0.4 (0.0)

2.0 (0.2)

1.5 (0.1)^†

1.2 (0.1)^†

O₂ extraction (%)

67.1 (3.4)

21.3 (4.3)

36.2 (6.3)^†

55.4 (8.0)^†

66.0 (2.5)

27.1 (1.3)^†

44.6 (4.6)^†

57.8 (4.0)^†

70.3 (2.7)

24.4 (2.6)^†

32.8 (5.1)^†

42.3 (5.8)^†

PaO₂ (mmHg)

84.8 (2.6)

81.5 (2.6)

80.9 (1.3)

83.0 (2.6)^†

91.8 (2.8)

78.8 (1.8)

83.4 (3.6)^†

86.6 (3.0)^†

86.0 (1.9)

80.8 (3.1)

80.7 (3.0)

82.8 (4.2)^†

PaCO₂ (mmHg)

29.2 (2.1)

37.5 (1.3)

34.9 (1.1)

29.9 (1.6)

27.6 (1.8)

38.2 (0.7)

34.4 (1.5)

32.0 (1.2)

26.7 (1.6)

36.4 (0.5)

35.7 (1.0)

32.2 (1.5)

tPO₂ (mmHg)

1.1 (0.9)

10.8 (4.4)^†

8.4 (3.5)^†

3.5 (2.8)^†

2.1 (1.1)

19.3 (5.4)^†

17.0 (4.9)^†

5.9 (2.2)^†

2.8 (1.4)

19.5 (2.7)^†

19.3 (2.3)^*†

12.9 (3.0)^†

pHa

7.20 (0.02)

7.28 (0.01)

7.33 (0.01)

7.34 (0.01)

7.19 (0.04)

7.29 (0.02)

7.36 (0.02)^†

7.33 (0.03)

7.17 (0.01)

7.33 (0.02)^†

7.37 (0.01)^†

7.37 (0.03)^†

BE (mM/L)

−17.0 (0.5)

−9.2 (0.6)

−7.3 (0.5)

−9.4 (1.3)

−18.7 (1.3)

−8.8 (1.1)

−6.2 (0.9)

−8.4 (1.5)

−18.7 (0.9)

−6.7 (1.2)

−4.8 (1.3)^†

−6.3 (2.2)

LA (mM/L)

7.0 (0.4)

4.8 (0.6)^†

3.8 (0.5)^†

5.0 (1.0)^†

7.3 (0.4)

4.9 (0.5)^†

3.9 (0.6)^†

5.3 (1.1)^†

7.4 (0.2)

4.2 (0.4)^†

2.9 (0.4)

3.4 (0.9)

SvO₂ (%)

30.7 (2.9)

74.2 (4.2)^†

60.6 (6.0)^†

42.6 (7.6)^†

32.2 (2.2)

68.7 (1.3)^†

52.9 (4.4)^†

40.5 (3.9)^†

27.8 (2.6)

71.8 (2.5)^†

64.1 (4.8)^†

55.1 (5.4)^†

(b)


Parameter (units)	HEX + CTRL				HEX + HIGH
Parameter (units)	Shock	End-dose	+1hr	End	Shock	End-dose	+1hr	End

PCV (%)	39.5 (1.3)	21.3 (1.7)^†	21.3 (1.4)^†	19.9 (1.4)^†	40.7 (1.5)	20.5 (1.5)^†	18.8 (1.2)^†	20.1 (1.2)^†
Total Hb (g/dL)	13.5 (0.4)	7.3 (0.6)^†	7.3 (0.5)^†	6.8 (0.5)^†	14.0 (0.5)	8.0 (0.5)^†	7.4 (0.4)^†	7.7 (0.4)^†
Plasma Hb (g/dL)	0.06 (0.01)	0.03 (0.01)^†	0.03 (0.01)^†	0.03 (0.01)^†	0.07 (0.02)	1.11 (0.02)^*†	1.02 (0.02)^*†	0.91 (0.01)^*†

MAP (mmHg)	41.7 (2.3)	90.3 (6.7)^†	84.7 (7.0)^†	63.1 (7.3)^†	40.0 (1.9)	110.8 (4.9)*	108.9 (5.5)*	81.0 (7.0)^*†
PAP (mmHg)	14.4 (0.6)	20.3 (1.9)	17.3 (1.7)^†	16.8 (1.7)^†	14.0 (1.2)	26.3 (1.7)^*†	19.8 (1.7)	17.5 (1.3)^†
HR (bpm)	195.7 (10.0)	187.6 (8.3)^†	196.9 (9.6)^†	209.6 (10.0)^†	211.7 (15.4)	192.4 (6.8)^†	197.1 (6.3)^†	206.3 (7.2)^†
CO (L/min)	0.4 (0.0)	1.8 (0.1)	1.4 (0.1)	1.0 (0.1)^†	0.5 (0.0)	2.1 (0.2)	1.6 (0.1)^†	1.2 (0.1)

O₂ extraction (%)	67.1 (3.4)	21.3 (4.3)	36.2 (6.3)^†	55.4 (8.0)^†	67.1 (1.2)	25.5 (2.5)^†	37.7 (3.0)^†	53.3 (2.3)^†
PaO₂ (mmHg)	84.8 (2.6)	81.5 (2.6)	80.9 (1.3)	83.0 (2.6)^†	82.8 (2.7)	75.8 (2.5)	74.6 (2.0)	78.3 (3.5)^†
PaCO₂ (mmHg)	29.2 (2.1)	37.5 (1.3)	34.9 (1.1)	29.9 (1.6)	28.3 (2.2)	38.8 (1.5)	37.1 (1.0)^†	32.2 (1.2)
tPO₂ (mmHg)	1.1 (0.9)	10.8 (4.4)^†	8.4 (3.5)^†	3.5 (2.8)^†	4.9 (1.5)	26.0 (3.0)*	24.7 (0.5)*	20.3 (1.2)^*†

pHa	7.11 (0.01)	7.28 (0.01)	7.33 (0.01)	7.34 (0.01)	7.20 (0.02)	7.34 (0.02)	7.39 (0.02)^†	7.41 (0.01)^†
BE (mM/L)	−17.0 (0.5)	−9.2 (0.6)	−7.3 (0.5)	−9.4 (1.3)	−16.8 (1.5)	−5.0 (1.3)*	−2.7 (1.2)^*†	−4.2 (1.1)^*†
LA (mM/L)	7.0 (0.4)	4.8 (0.6)^†	3.8 (0.5)^†	5.0 (1.0)^†	6.9 (0.3)	4.5 (0.5)^†	2.9 (0.3)	3.4 (0.3)
SvO₂ (%)	30.7 (2.9)	74.2 (4.2)^†	60.6 (6.0)^†	42.6 (7.6)^†	30.8 (1.2)	70.0 (2.3)^†	59.0 (3.0)^†	44.6 (2.1)^†

Data are mean values (standard error of the mean).
(adjusted) versus HEX + LRS; (adjusted) versus baseline (BASE), excluding “Shock” (not compared).