Elective neurosurgical patients (tumors and aneurysm clippings) ICP measured via LD Anesthetic: thiopental induction, sevoflurane, maintenance, pCO2 goal 33–35 mm Hg
Primary: to determine the effect of esmolol versus lidocaine IV bolus (130 sec before intubation) on lumbar cistern pressures during laryngoscopy (ICP measured before, during, and 2 and 5 min after intubation) Secondary: MABP, CPP
Severe TBI Concurrent ICP therapy: not specific, hyperventilated to pCO2 goal of 25 to 30 mm Hg
Primary: to determine the effect of IV and LT lidocaine on ICP during suctioning Secondary: not stated
= number of patients, HR = heart rate, MABP = mean arterial blood pressure, ICP = intracranial pressure, CPP = cerebral perfusion pressure, CSF = cerebrospinal fluid, mmHg = millimeters of mercury, IV = intravenous, LT = laryngotracheal, TBI = traumatic brain injury, LD = lumbar drain, and sec = second. Donegan and Bedford  and Donegan et al.  are companion publications, with Donegan et al.  representing the meeting abstract published prior to the full manuscript . The data from Donegan et al.  is not included in the synthesis of data and is only included in the tables for completeness.