Contemporary Trends of the Epidemiology, Clinical Characteristics, and Resource Utilization of Necrotizing Fasciitis in Texas: A Population-Based Cohort Study
Table 2
Changes in the epidemiology, patient characteristics, resource utilization, and outcomes of NF hospitalizations.
Variable
2001-2002 (n = 1,976)
2009-2010 (n = 2,926)
P
Age-adjusted incidence (per 105 population/yrs)
All
5.9
7.6
<0.0001
Hispanic
7.1
7.1
0.9203
Black
8.3
8.9
0.4140
White
4.7
7.0
<0.0001
Other
9.8
14.3
0.0008
Age ≥65 years (n, %)
540 (27.3)
694 (23.7)
0.0048
Any chronic comorbidity ( [%])a
1,371 (69.4)
2,244 (76.7)
<0.0001
Deyo-Charlson score [mean (SD)]
1.6 (1.7)
2.1 (2)
<0.0001
Obesity (, %)
139 (7)
677 (23.1)
<0.0001
Number of failing organs
Median (IQR)
0 (0-1)
1 (0–2)
<0.0001
≥3 Organ failures (%)
117 (5.9)
534 (18.3)
<0.0001
Organ failures ( [%])
Respiratory
299 (15.1)
776 (26.5)
<0.0001
Cardiovascular
192 (9.7)
686 (23.4)
<0.0001
Renal
214 (10.8)
949 (32.4)
<0.0001
Hepatic
14 (0.7)
85 (2.9)
<0.0001
Hematological
128 (6.5)
338 (11.6)
<0.0001
Metabolic
96 (4.9)
340 (11.6)
<0.0001
Neurological
24 (1.2)
197 (6.7)
<0.0001
Life-support interventions ( [%])
Mechanical ventilation
173 (8.8)
505 (17.3)
<0.0001
CVCb
362 (18.3)
1088 (37.2)
<0.0001
Hemodialysis
45 (2.3)
136 (4.6)
<0.0001
New hemodialysis
13 (0.7)
52 (1.8)
0.0012
Hospital length of stay, days
Median (IQR)
14 (7–25)
13 (7–25)
0.2911
Mean (SD)
19.3 (18.6)
19.1 (19.7)
Total hospital charges, dollarsc
Median (IQR)
65,808 [34,036–135,468]
90,460 [46,278–167,262]
<0.0001
Mean (SD)
115,635 (146,549)
142,683 (179,948)
Mortality rate (per 105 population)
0.61
0.74
0.0428
Patient disposition ( [%])
Hospital mortality
203 (10.3)
287 (9.8)
0.6287
Routine discharge
791 (40)
822 (28.1)
<0.0001
Home health care
313 (15.8)
668 (22.8)
<0.0001
Short-term facility
323 (16.3)
200 (6.8)
<0.0001
Long-term facility
242 (12.2)
879 (30)
<0.0001
Otherd
31 (1.6)
55 (1.9)
0.4825
Missing
73 (3.7)
15 (0.5)
<0.0001
Based on the Deyo-Charlson comorbidity index; bcentral venous catheterization; chospital charges are adjusted for inflation to 2010 dollars; dleft against medical advice, hospice.
