Achievement of Vancomycin Therapeutic Goals in Critically Ill Patients: Early Individualization May Be Beneficial

Table 2

Frequencies of patients who have subtherapeutic levels with regard to specific pharmacokinetic targets.

	Frequencies	Group 1	Group 2	Sig. (2-sided)
		%	%
	Number of patients	8	10	—
Steady state	Trough <15 (mg/L)	62.5	10	0.043
	Trough <12.5 (mg/L)	50	0	0.023
	Trough <10 (mg/L)	12.5	0	0.444
	AUC <400 (mg⋅hr/L)	14.3	0	0.041
	AUC <600 (mg⋅hr/L)	85.7	30	0.050

AUC: area under the curve.