Neutropenic Sepsis in the ICU: Outcome Predictors in a Two-Phase Model and Microbiology Findings

Table 1

Characteristics of patients who manage to overcome the initial sepsis compared to those who decease in the initial septic episode. Values are displayed as mean ± standard deviation; // indicate level of significance.

Parameter	Initial sepsis, survived ()	Initial sepsis, deceased ()	value	Odds ratio
Male	65,1% ()	69,2% ()	0,666	1,207
Female	34,9% ()	30,8% ()	0,666	0,828
Age	55,1 ± 14,9 ()	54,6 ± 11,9 ()	0,613	0,997
Days in the ICU	16,9 ± 17,0 ()	8,5 ± 7,6 ()	0,020	0,944
Duration prior to leukopenia	10,8 ± 16,3 ()	17,8 ± 18,5 ()	0,012	1,024
Respiratory frequency	26,1 ± 7,6 ()	29,5 ± 8,0 ()	0,032	1,058
First Lactate (mg/dL)	23,2 ± 19,3 ()	36,4 ± 37,8 ()	0,237	1,017
APACHE II on admission	22,8 ± 8,4 ()	29,0 ± 11,2 ()	0,003	1,069
SOFA on admission	7,3 ± 4,8 ()	10,1 ± 5,4 ()	0,011	1,115
Intubation	55,6% ()	89,7% ()	0,000	7,000
Lowest oxygenation index	112,8 ± 80,2 ()	81,4 ± 44,4 ()	0,035	0,99
Vasopressors in the first 24 h	63,5% ()	61,5% ()	0,843	0,92
Maximal noradrenaline dose (mg/h)	2,9 ± 3,2 ()	5,7 ± 3,7 ()	0,000	1,280
Fluid administration in the first 24 h (mL)	6710,8 ± 2527,0 ()	8960,5 ± 4790,8 ()	0,020	1,000
MAP first 24 h	56,1 ± 14,4 ()	55,1 ± 11,7 ()	0,617	0,994
Liver failure on admission	42,9% ()	66,7% ()	0,019	2,667
Lowest bilirubin	1,4 ± 1,7 ()	2,4 ± 2,8 ()	0,023	1,249
Lowest INR	1,2 ± 0,17 ()	1,4 ± 0,2 ()	0,000	49,677
Lowest urine output (mL/24 h)	1303,5 ± 1068,6 ()	540,1 ± 693,0 ()	0,000	0,999
Kidney failure	52,4% ()	79,5% ()	0,006	3,523
Renal replacement therapy	33,3% ()	71,8% ()	0,000	5,091
GCS on admission	12,7 ± 3,9 ()	13,1 ± 3,3 ()	0,876	1,031
GCS highest	14,6 ± 1,3 ()	13,2 ± 3,3 ()	0,002	0,735
Erythrocyte concentrates (units/day)	0,6 ± 1,1 ()	1,1 ± 0,9 ()	0,000	1,752
Platelet concentrates (units/day)	0,6 ± 0,6 ()	1,0 ± 0,6 ()	0,000	2,773
Fresh frozen plasma (units/day)	0,5 ± 0,8 ()	2,2 ± 2,8 ()	0,000	2,763
CRP highest first 10 days (mg/dL)	30,6 ± 9,9 ()	34,8 ± 16,8 ()	0,214	1,026
CRP lowest (mg/dL)	10,2 ± 8,7 ()	19,1 ± 10,8 ()	0,000	1,100
Persistent leukopenia	36,5% ()	82,1% ()	0,000	7,950