Neutropenic Sepsis in the ICU: Outcome Predictors in a Two-Phase Model and Microbiology Findings

Table 2

Comparison of patients in the recovery phase after overcoming the initial sepsis. Values are displayed as mean ± standard deviation; / indicate level of significance.

Parameter	Recovery phase, survived ()	Recovery phase, deceased ()	value	Odds ratio
Male	65,2% ()	64,7% ()	0,970	0,978
Female	34,8% ()	35,3% ()	0,970	1,023
Age	57,0 ± 13,9 ()	50,1 ± 16,7 ()	0,152	0,969
Days in the ICU	13,3 ± 13,5 ()	26,7 ± 21,6 ()	0,004	1,047
Duration prior to leukopenia	9,0 ± 15,8 ()	16,2 ± 17,3 ()	0,086	1,024
Respiratory frequency	25,7 ± 7,8 ()	27,4 ± 7,1 ()	0,243	1,031
First lactate (mg/dL)	21,0 ± 15,6 ()	29,0 ± 26,5 ()	0,368	1,02
APACHE II on admission	22,3 ± 7,8 ()	24,0 ± 9,9 ()	0,837	1,025
SOFA on admission	7,0 ± 4,7 ()	8,1 ± 5,2 ()	0,462	1,045
Intubation	39,1% ()	100% ()	0,000	53,919
Lowest oxygenation index	126,7 ± 94,2 ()	90,8 ± 45,3 ()	0,185	0,991
Tracheotomy	21,7% ()	64,7% ()	0,001	6,600
Lung failure after initial crisis	45,7% ()	94,1% ()	0,001	19,048
Vasopressors in the first 24 h	56,5% ()	82,4% ()	0,059	3,59
Maximal Noradrenaline dose (mg/h)	1,9 ± 1,6 ()	4,7 ± 4,2 ()	0,009	1,466
Fluid administration in the first 24 h (mL)	6670,7 ± 2375,0 ()	6819,5 ± 2977,2 ()	1,000	1
MAP first 24 h	56,0 ± 15,2 ()	56,6 ± 12,0 ()	0,643	1,003
Circulatory failure after initial crisis	4,3% ()	23,5% ()	0,021	6,769
Liver failure on admission	43,5% ()	41,2% ()	0,870	0,91
Lowest bilirubin	1,3 ± 1,2 ()	1,8 ± 2,6 ()	0,963	1,185
Lowest INR	1,2 ± 0,2 ()	1,2 ± 0,2 ()	0,871	0,792
Liver failure after initial crisis	37% ()	58,8% ()	0,120	2,437
Lowest urine output (mL/24 h)	1548,5 ± 1089,2 ()	640,5 ± 669,4 ()	0,001	0,999
Kidney failure	41,3% ()	82,4% ()	0,004	6,632
Renal replacement therapy	21,7% ()	64,7% ()	0,001	6,600
GCS on admission	12,7 ± 4,1 ()	12,8 ± 3,4 ()	0,871	1,005
GCS highest	15,0 ± 0,1 ()	13,7 ± 2,4 ()	0,000	0,070
Erythrocyte concentrates (units/day)	0,6 ± 1,2 ()	0,7 ± 0,5 ()	0,003	1,111
Platelet concentrates (units/day)	0,5 ± 0,7 ()	0,8 ± 0,5 ()	0,008	2,002
Fresh frozen plasma (units/day)	0,4 ± 0,9 ()	0,7 ± 0,6 ()	0,000	1,567
CRP highest in the first 10 days (mg/dL)	28,9 ± 8,8 ()	35,3 ± 11,5 ()	0,068	1,073
CRP lowest (mg/dL)	8,2 ± 6,5 ()	15,6 ± 11,4 ()	0,008	1,106
Persistent leukopenia	30,4% ()	52,9% ()	0,100	2,571