Brain Multimodality Monitoring: A New Tool in Neurocritical Care of Comatose Patients

Figure 2

(Not to scale) Cerebral Autoregulation Curve. Autoregulation ensures nearly constant CBF despite changes in perfusion pressure over a certain range (~50–150 mmHg). In healthy brain over 150 mmHg there is endothelial damage, leading to impaired vessel reactivity resulting in hyperemia, vasogenic edema, and intracranial hypertension. Under 50 mmHg CBF becomes directly proportional to perfusion pressure with risk of arterial collapse and ischemia.