The Role of Antifungals in Pediatric Critical Care Invasive Fungal Infections

Table 3

Clinical indications and pediatric dosing of conventional and liposomal preparations of amphotericin B [13, 21].

Drug	Indications	Dose	Special comments
Amphotericin B	Neonates with disseminated candidiasis including CNS disease candidiasis, invasive candidiasis, mucosal aspergillosis; cryptococcal meningitis; coccidioidomycosis; histoplasmosis; blastomycosis; mucormycosis; sporotrichosis	1 mg/kg/day intravenously	Conventional preferred for; 1. Neonatal candidiasis; 2. Chorioretinitis with vitritis (intravitreal injection of 5–10 µg/0.1 mL sterile water); 3. Intraventricular use: device-related CNS candidiasis; when device cannot be removed: amphotericin B intraventricular through device at 0.01 mg–0.5 mg in 2 mL 5% dextrose in water
Liposomal amphotericin B	Same as above with exceptions noted above	3–5 mg/kg/day intravenously