Relationship between Microcirculatory Perfusion and Arterial Elastance: A Pilot Study

Table 2

Hemodynamic and microvascular perfusion parameters, with regard to responsiveness to fluid challenge (FC).

Variable	All patients ()		Responders ()		Nonresponders ()
	Baseline	After FC	Baseline	After FC	Baseline	After FC
Global hemodynamics
MAP (mmHg)	71 [68–81]	74 [71–77]	79 [69–88]	74 [72–84]	69 [65–71]	73 [71–74]
CVP (mmHg)	7 [7–11]	10 [8–12]	7 [6–7]	9 [7–10]	10 [9–12]	10 [10–12]
HR (bpm)	94 [81–102]	90 [80–103]	94 [82–102]	93 [80–104]	90 [81–100]	87 [80–94]
CO (L/min)	4.3 [3.5–5.0]	4.9 [4.2–5.4]	4.4 [3.4–5.0]	5.0 [4.6–5.5]	4.0 [3.5–5.2]	4.8 [3.9–5.0]
Ea (mmHg/ml)	1.4 [1.2–1.6]	1.2 [1.1–1.4]	1.4 [1.3–1.7]	1.2 [1.1–1.5]	1.3 [1.1–1.5]	1.2 [1.1–1.3]
SVR (dyn ∗ s/cm^5)	1207 [1006–1373]	1073 [997–1202]	1266 [1082–1751]	1073 [1002–1185]	1091 [883–1256]	1056 [963–1233]
Lactate, mmol/L	1.7 [0.9–2.2]	1.7 [0.9–2.1]	1.6 [1.0–2.0]	1.7 [0.9–2.1]	1.7 [0.9–2.9]	1.7 [0.9–2.3]
Microcirculation
PPV (%)	56 [51–64]	59 [47–73]	56 [51–64]	58 [44–73]	57 [49–67]	60 [55–72]
TVD (mm/mm^2)	17 [14–19]	17 [16–20]	18 [15–21]	18 [16–21]	15 [13–16]	15 [13–16]
PVD (mm/mm^2)	9 [7–11]	10 [8–12]	10 [8–12]	10 [7–13]	7 [5–9]	10 [9–12]

FC, fluid challenge; MAP, mean arterial pressure; HR, heart rate; CO, cardiac output; Ea, arterial elastance; SVR, systemic vascular resistances; PPV, proportion of perfused small vessels; TVD, total vessel density; PVD, perfused small vessel density, p < 0.05.