Intravenous Fluid of Choice in Major Abdominal Surgery: A Systematic Review

Table 9

Overview of randomized control trials related to return of bowel function by primary outcome.

Author, year	Fluid compared	N	Operation	Conclusion
Primary outcome: return to bowel function, ileus, passing flatus, defecation, or enteral food tolerance
Yates [16], 2014	Hartmann’s solution; 6% HES 130/0.4 (Volulyte)	202	Colorectal surgery	No difference in bowel recovery time
Loffel [32], 2016	Chloride-depleted glucose solution 5% (G5K); Ringer maleate	44	Cystectomy	G5K group could pass normal stool faster than RM (38 hours)
Ghodraty [22], 2017	LRS; 6% HES 130/0.4 (Voluven)	91	GI surgery	HES 130/0.4 reduced time of postoperative ileus (13 hours)
Primary outcome was another objective but also had these outcomes
Zhang [56], 2012	Restricted-LRS (20); GD-LRS (20); GD-HES130/0.4 (20)	60	GI surgery	Goal-directed HES 130/0.4 reduced time to pass flatus (6 hours compared to restricted group and 9 hours compared to GD-LRS)

HES = hydroxyethyl starch, LRS = lactated Ringer’s solution, GI = gastrointestinal, and GD = goal-directed therapy.