Effect of Exogenous Melatonin Administration in Critically Ill Patients on Delirium and Sleep: A Randomized Controlled Trial

<div>Control versus melatonin subject’ hypnogram. R, REM stage; <i>N</i>1–<i>N</i>3, non-REM stages. Comparison between normal sleep stages in a healthy subject (hypnogram a) and one of the melatonin subjects (hypnogram b) showing absence of REM and non-REM sleep stages and presence of numerous arousals through all stages of sleep.</div>

Critical Care Research and Practice

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Figure 3: Effect of Exogenous Melatonin Administration in Critically Ill Patients on Delirium and Sleep: A Randomized Controlled Trial 