Area under the Curve-Based Dosing of Vancomycin in Critically Ill Patients Using 6-Hour Urine Creatinine Clearance Measurement

Table 1

Pharmacokinetic parameters of vancomycin.

Measures	Mean ± S.D. or median (1^st quarterly and 3^rd quarterly)
t1/2 (hr)	5.7 [5.2, 7.0]
Vd/kg (L/kg)	0.75 ± 0.23
CLvan (mL/min)	96.2 ± 29.9
AUC24 h (mg.hr/L)	518 [447, 641]

Abbreviations: S.D.: standard deviation, C_p: peak concentration, C_t: trough concentration, t_1/2: half-life, V_d/kg: volume of distribution per kilogram, CL_van: clearance of vancomycin, and AUC_24 h: 24-hour area under the curve.