Assessment of Metabolic Dysfunction in Sepsis in a Retrospective Single-Centre Cohort
Table 1
Main characteristics of hospital survivors and nonsurvivors to infections at 90 days.
In-hospital survivors within 90 days (n = 661)
In-hospital nonsurvivorsg within 90 days (n = 295)
ASD (%)
Age (years)
60 (50, 70)
66 (58, 77)
45.6
Male sex, n (%)
419 (63.4)
181 (61.4)
4.2
Weight (kg)
76 (65; 91)
75 (65; 90)
6.5
Medical history
Chronic pulmonary disease
192 (29.0)
88 (29.8)
1.7
Diabetes
149 (22.5)
71 (24.1)
0.5
Chronic heart failure
102 (15.4)
69 (23.4)
20.2
Coronary arterial disease
86 (13.0)
61 (20.7)
20.6
Peripheral arterial disease
64 (9.7)
38 (12.9)
10.1
Stroke
90 (13.6)
60 (20.3)
12.7
Cognitive disorder
22 (3.3)
19 (6.4)
14.5
Diffuse connect tissue disease
38 (5.7)
27 (9.2)
13.0
Peptic ulcer disease
11 (1.7)
10 (3.4)
11.0
Liver disease
42 (6.4)
37 (12.5)
21.3
Chronic renal failure (mild to severe)
46 (7.0)
34 (11.5)
15.8
Solid cancer
142 (21.5)
86 (29.2)
17.7
Leukemia
48 (7.3)
36 (12.2)
16.7
Lymphoma
24 (3.6)
23 (7.8)
18.0
HIV infection
1 (0.1)
2 (0.7)
8.2
Immunocompromised
135 (20.4)
90 (30.1)
23.3
Charlson’s comorbidity score
2 [1–4]
3 [2–6]
60.5
Baseline SOFA
0 [0–0]
0 [0–0]
2.9
Severity scores and metabolic parameters within 24 hours after ICU admission
SOFA
5 (3, 8)
9 (6, 13)
96.5
Maximal lactatemia, (mmol/L)
1.6 (1.0; 2.6)
2.9 (1.5; 5.1)
69.9
Minimal glycaemia (g/L)
1.1 (0.9; 1.3)
1.0 (0.8; 1.3)
15.1
Maximal glycaemia (g/L)
1.6 (1.3; 2.1)
1.6 (1.2; 2.2)
4.1
Minimal temperature (°C)
36.5 (36.0; 37.1)
36.4 (35.8; 37.1)
12.5
Maximal temperature (°C)
37.9 (37.2; 38.6)
37.8 (36.8; 38.7)
9.8
Total serum cholesterol (g/L)
1.1 (0.8; 1.4)
0.9 (0.7; 1.3)
30.3
Total serum triglycerides (g/L)
1.1 (0.8; 1.7)
1.1 (0.8; 1.6)
5.5
Characteristics at hospital discharge
ICU LOS, days
8 (4, 16)
5 (2, 14)
—
Hospital LOS, days
16 (8, 29)
7 (2, 19)
—
Glasgow outcome scale
4 (4, 5)
1
—
Rankin score
1 (0; 2)
6
—
Values are expressed as counts (%) or medians (25th; 75th centiles). ASD, absolute standardized difference, ICU, intensive care unit; LOS, length of stay; SOFA : sequential organ failure Assessment. Missing metabolic parameters were as follows: no patients lacked data for body temperature, 1 (0.1%) lacked data for glycaemia, 36 (3.8%) for lactatemia, and 151 (15.8%) for both cholesterolemia and triglyceridemia. No missing data.
