Assessment of Metabolic Dysfunction in Sepsis in a Retrospective Single-Centre Cohort

Table 3

The metabolic failure, age, and comorbidity assessment (MACA) score.

Parameters	Categories
Maximal lactatemia (mmol/L)	<1	[1.0–2.0)	[2.0–4.0)	[4.0–6.0)	≥6
Number of patients	149	340	256	84	91
Regression coefficients	(Ref)	0.74	2.03	3.76	13.3
Attributed points	0	1	2	4	13
Age	<40	[40–55)	[55–65)	[65–80)	≥80
Number of patients	102	177	227	333	117
Regression coefficients	(Ref)	3.70	6.02	8.34	11.40
Attributed points	0	4	6	8	11
Charlson’s comorbidity score	0–1	2–3	4–5	6–7	≥8
Number of patients	318	337	147	60	94
Regression coefficients	(Ref)	2.08	4.17	6.25	10.94
Attributed points	0	2	4	6	11

The metabolic failure, age and comorbidity assessment (MACA) score according to maximal lactatemia within the first 24 hours of intensive care admission and to background characteristics (i.e: age and Charlson’s comorbidity score). Regression coefficients associated with maximal lactatemia, age, or Charlson’s score calculated using the Framingham method to reflect the increase associated with one point of the sequential organ failure assessment (SOFA) score. The notation [a-b) indicates an interval from a to b, that, is inclusive of a but exclusive of b.