Prevalence and Trajectory of COVID-19-Associated Hypercoagulability Using Serial Thromboelastography in a South African Population

Table 3

Factors associated with mortality.

Initial variable	Survivors		Nonsurvivors		-value
	Valid n	Median (IQR)	Valid n	Median (IQR)
SOFA score	23	2 [2–3]	18	4 [2–6]	0.017
SAPS2 score	23	20 [18–26]	18	28 [21–43]	0.006
DIC score	23	2 [0–2]	18	2 [0–3]	0.112
SIC score	23	2 [2–3]	18	2 [2–3]	0.490
Platelets x 10  9/L	23	269 [244–328]	18	196 [167–264]	0.004
Haemoglobin g/dL	23	13.3 [11.6–14.2]	18	13.2 [11.3–14.3]	0.765
LDH u/L	15	513 [413–757]	12	889 [387–1051]	0.003
Fibrinogen mg/dL	15	6.7 [6.0–7.5]	12	6.5 [5.35–7.95]	0.980
D-dimers mg/L	21	0.56 [0.34–0.97]	17	0.96 [0.39–2.12]	0.089
INR	22	1.11 [1.05–1.19]	17	1.13 [1.07–1.18]	0.440
PT sec	21	13.4 [12.8–14.2]	17	13.5 [13.1–14.4]	0.601
aPTT sec	21	25.2 [21.9–26.5]	15	29.9 [22.8–32.6]	0.141
LY30-CK (%)	23	0.1 [0.00–2.00]	18	0 .0 [0.0–0.0]	0.006
R–CKH	23	4.9 [4.2–5.5]	18	4.0 [3.4–5.2]	0.138
K–CKH	23	0.8 [0.8–1.0]	18	1.0 [0.8–1.8]	0.081
Ang-CKH	23	78.2 [75.3–79.6]	18	75.95 [69.90–78.10]	0.031
MA-CKH	23	69.1 [66.5–70.4]	18	68.3 [53.4–69.4]	0.040

Statistically significant. Data are expressed as median (interquartile range). LDH: lactate dehydrogenase, PT: prothrombin time, aPTT: activated partial thromboplastin time, INR: international normalised ratio, SOFA: sequential organ failure assessment, SAPS2: simplified acute physiology score 2, DIC: disseminated intravascular coagulopathy, SIC: sepsis-induced coagulopathy, TEG: thromboelastography, CKH: citrated kaolin heparinase, R: reaction, K: kinetics, MA: maximum amplitude, LY30: lysis at 30 minutes, Ang: angle, Anti-Xa: antifactor Xa.