The Performance of Equations That Estimate Glomerular Filtration Rate against Measured Urinary Creatinine Clearance in Critically Ill Patients
Table 4
Correlation between equations estimating glomerular filtration rate and creatinine clearance measured by 24-hour urine collection.
Spearman correlation (r)
CGactual-wt
CGideal-wt
CGadjusted-wt
MDRD-4
MDRD-6
CKD-EPI
Jelliffe
Age ≥ 65 years (N = 53)
0.70
0.62
0.67
0.60
0.61
0.67
0.61
Age < 65 years (N = 184)
0.71
0.62
0.69
0.57
0.56
0.57
0.58
BMI ≥ 30 kg/m2 (N = 77)
0.82
0.82
0.83
0.76
0.73
0.81
0.78
BMI < 30 kg/m2 (N = 160)
0.73
0.73
0.73
0.61
0.64
0.63
0.64
Admission category: medical (N = 112)
0.79
0.72
0.78
0.63
0.66
0.70
0.67
Admission category: surgical (N = 11)
0.74
0.58
0.68
0.70
0.48
0.66
0.67
Admission category: nonoperative trauma (N = 114)
0.54
0.37
0.46
0.34
0.30
0.22
0.32
APACHE II ≥ 20 (N = 118)
0.77
0.74
0.77
0.68
0.67
0.71
0.71
APACHE II < 20 (N = 119)
0.71
0.59
0.67
0.48
0.46
0.53
0.55
Diabetes (N = 75)
0.78
0.70
0.77
0.65
0.62
0.67
0.68
No diabetes (N = 162)
0.70
0.62
0.68
0.52
0.52
0.57
0.55
Sepsis admission (N = 51)
0.76
0.74
0.77
0.62
0.64
0.69
0.65
No sepsis on admission (N = 186)
0.74
0.66
0.72
0.59
0.57
0.61
0.62
Traumatic brain injury (N = 62)
0.56
0.39
0.49
0.41
0.43
0.21
0.32
No traumatic brain injury (N = 175)
0.78
0.72
0.77
0.64
0.63
0.70
0.67
SOFA renal > 0 (Cr ≥ 110 μmol/L) (N = 49)
0.90
0.86
0.90
0.82
0.82
0.81
0.85
SOFA renal = 0 (Cr < 110 μmol/L) (N = 188)
0.64
0.54
0.62
0.41
0.43
0.45
0.46
Acute kidney injury on admission (N = 43)
0.79
0.68
0.75
0.68
0.63
0.68
0.70
No acute kidney injury on admission (N = 188)
0.65
0.56
0.63
0.41
0.45
0.46
0.47
Baseline CrCl24h-urine ≥ 130 ml/min (N = 91)
0.38
0.26
0.36
0.27
0.17
0.22
0.23
Baseline CrCl24h-urine< 130 ml/min (N = 146)
0.70
0.68
0.70
0.62
0.62
0.71
0.64
APACHE: acute physiology and chronic health evaluation; BMI: body mass index; CKD-EPI: chronic kidney disease epidemiology collaboration; CG: Cockroft-Gault; CrCl24h-urine: creatinine clearance measured by 24-hour urine collection; GFR: glomerular filtration rate; MDRD: modification of diet in renal disease study. CGactual-wt: the CG equation was calculated using actual body weight. CGideal-wt: the CG equation was calculated using ideal body weight. CGadjusted-wt: the CG equation was calculated using adjusted body weight. MDRD-4: the MDRD equation was calculated using four variables. MDRD-6: the MDRD equation was calculated using six variables.
