Naloxegol to Prevent Constipation in ICU Adults Receiving Opioids: A Randomized Double-Blind Placebo-Controlled Pilot Trial

Figure 2

Time to first spontaneous bowel movement from the time of enrolment. The Kaplan–Meier curve for the time to the first spontaneous bowel movement occurrence between the naloxegol and placebo groups during the ICU stay from the time of enrolment (log rank value = 0.56). The naloxegol and placebo lines at the bottom of the figure refer to the patients still receiving study drug.