Ketamine Infusion for Sedation and Analgesia during Mechanical Ventilation in the ICU: A Multicenter Evaluation

Table 1

Baseline patient characteristics (overall and stratified by ketamine dose).

Variable	Ketamine dose group			All patients (N = 95)
	0.1–0.99 mg/kg/hr (N = 27)	1.0–1.49 mg/kg/hr (N = 32)	1.5–2.4 mg/kg/hr (N = 36)
Age, y	50 (39–62)	51 (32–61)	47 (33–59)	50 (35–61)
Male sex	15 (56%)	22 (69%)	26 (72%)	63 (66%)
BMI, kg/m^2	26 (23–32)	25 (23–32)	28 (24–32)	26 (23–32)
SOFA score	10 (8–14)	10 (6–12)	8 (6–11)	9 (7–12)
Reason for ICU admission
Respiratory failure	7/23 (30%)	7/23 (30%)	9/23 (39%)	23 (24%)
Status epilepticus	4/13 (31%)	6/13 (46%)	3/13 (23%)	13 (14%)
Trauma including burns	4/12 (33%)	6/12 (50%)	2/12 (17%)	12 (13%)
Septic shock	3/12 (25%)	4/12 (33%)	5/12 (42%)	12 (13%)
Cardiovascular disease	2/11 (18%)	4/11 (36%)	5/11 (45%)	11 (12%)
Overdose	1/7 (14%)	1/7 (14%)	5/7 (71%)	7 (7%)
Asthma/COPD	1/6 (17%)	2/6 (33%)	3/6 (50%)	6 (6%)
Other	5/11 (45%)	2/11 (18%)	4/11 (36%)	11 (12%)

Values are given as median (interquartile range) or count (percentage). SOFA score is missing for 13 patients (N = 82). other reason for ICU admission: gastrointestinal hemorrhage (N = 4), procedure (N = 3), diabetic ketoacidosis (N = 1), severe pancreatitis (N = 1), environmental hypothermia (N = 1), and ischemic stroke (N = 1). BMI, body mass index; SOFA, sepsis related organ failure assessment score; ICU, intensive care unit.